Chronic pain exists along a continuum from acute injury to long-standing, centralized pain shaped by neuroplastic changes, trauma, and stress-related learning in the brain and body. Advances in neuroscience and epigenetics show how adverse experiences can alter pain processing and gene expression over time, helping explain why pain may persist even after tissue healing. Accurate identification of pain type is essential for selecting appropriate treatments, including pharmacologic options, while also recognizing the risks associated with long-term opioid therapy, complex persistent opioid dependence, and opioid use disorder. This program will look at current evidence to build integrated, patient-centered strategies that address pain, trauma, and opioid related risk together. Participation is free. Pre-registration is required.