Stem Cells 101
Sanford Research scientists recently published a review article in an issue of Stem Cells Translational Medicine focused on the study of and utility of adult-derived stem cells.
The article, “Fat and Furious: Harnessing the Full Potential of Adipose-Derived Stromal Vascular Fraction,” is a review of the various types of stem cells found in humans and how they can be used in medical applications.
In the article, the researchers emphasize the difference between the stromal vascular fraction (SVF) isolated from adipose tissue and the pure adipose-derived stem cells that have been purified and maintained in a culture dish. Understanding those differences can help dictate appropriate therapies and regulations, particularly in countries where the SVF could be less regulated than other stem cells. It’s also important to understand how SVF composition varies in healthy versus disease states.
“Continued research into the application of SVF and adipose derived stem cells has the potential to transform treatments and therapy options,” said Daniel Kota, assistant research scientist for Sanford Research and an author on the paper. “But it all starts with putting scientists on the same page – tracking results following transfusions, using appropriate nomenclature and examining regulations.”
Last month, Sanford began enrolling participants in the “Safety and Efficacy of Adult Adipose-Derived Stem Cell Injections into Partial Thickness Rotator Cuff Tears” clinical trial. The trial uses stromal vascular fraction (SVF), a mixture of cells and nutrients isolated from a patient’s own body, that contain adipose-derived stem cells, as a potential therapy for partial-thickness rotator cuff tears. Sanford scientists and clinicians are exploring the application of this type of stem cells for other conditions.